Psychiatry and Behavioral Health Conference-NAPC 2026

Treatment-resistant depression (TRD) refers to depressive disorders that do not respond adequately to standard treatment approaches. It presents significant challenges for both patients and clinicians.

This session defines TRD and discusses criteria used to identify patients who have not responded to multiple treatment trials.

Participants will explore underlying causes of treatment resistance, including biological, psychological, and social factors.

The session highlights advanced treatment options such as combination therapies, augmentation strategies, and novel pharmacological agents.

Non-pharmacological interventions, including electroconvulsive therapy (ECT), transcranial magnetic stimulation (TMS), and psychotherapy, are discussed.

The importance of individualized care and continuous monitoring is emphasized to improve outcomes.

Emerging research and innovative approaches in managing TRD are also presented.

Attendees will gain a comprehensive understanding of TRD and effective strategies to manage complex depressive conditions.